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Earlier work in psychosis risk largely focused on single substances, whereas our approach captures the real-world scenario where many young people use tobacco and cannabis together

In the MR Steiger directionality test, the variance explained by included SNPs is larger in schizophrenia, bipolar disorder and anxiety compared with smoking initiation, suggesting that these observed associations might not be directionally causal

Nicotine, through its influence on nAChRs and the downstream effects, has been shown to remediate the deficits in P50 suppression for this population (35, 124, 125)

A fast-playing SlimTaper 60s Rounded C mahogany neck with a sculpted heel provides comfortable access across the entire laurel fretboard

Nicotines addictive nature creates a compulsive need to spend on tobacco, even at the expense of basic needs